Determinants of ocular symptoms in postmenopaual women with dry eye.

摘要: Purpose: Dry eye in women is more prevalent postmenopause and alterations sex hormone levels may be implicated. This study explored the relationship between serum concentration of hormones dry symptoms ocular surface signs. Methods: The involved 46 postmenopausal diagnosed with non-Sjogrens not taking replacement therapy (mean age 64±5 years, 14±6 years since menopause). following measurements were conducted at a single timepoint: Ocular (Ocular Surface Disease Index (OSDI) Comfort (OCI)), tear function (non-invasive break-up time (NITBUT), osmolarity (TearLab), volume (Phenol Red Thread Schirmer tests)), staining meibomian gland assessment using grading scales, sensitivity (Cochet-Bonnet aesthesiometer) venous blood collection. Serum concentrations 17β-estradiol (E2), 3α-diol-G, DHEA-S their ratios determined Enzyme-linked immunosorbent assay (ELISA). Univariate associations examined Spearman’s correlations multiple linear regression analysis was subsequently used to examine predictors symptoms. Results: Mean E2 10.8±19.7pg/ml, 2.10±2.77ng/ml 3α-diol-G 0.73±0.55μg/ml DHEA-S. scores 27.0±18.1 40.3±8.4 (OCI). Only secretion quality significant OSDI model; this model explained 20% variance score (F(6, 39)=2.858, p=0.02, R2adj= 0.20). Eyelid vascularity expressibility OCI dryness frequency model, explaining 29% 39)=4.015, p=0.003, R2adj=0.29). Although associated on univariate correlations, E2, or found full multivariate model(p>0.05). Conclusions: Meibomian lid variables are eye, but shown play role study. These findings would suggest that disease underpins cohort examination lager required further elucidate women.