Circulating microRNAs as emerging non-invasive biomarkers for gliomas

摘要: No single circulating biomarker has been put to practice for malignant gliomas so far, the most lethal primary brain tumors. Many promising protein biomarkers such as mutant EGFRvIII or glial fibrillary acidic (GFAP) have already detected in blood and cerebrospinal fluid (CSF) of patients with gliomas, but their clinical value is still pending validation. Furthermore, these other proteins seem lack sufficient sensitivity specificity required a successful this setting. The expression profiling microRNAs (miRNAs) entered cancer clinics diagnostic prognostic biomarkers, assessing tumor initiation, progression response treatment. Large-scale miRNA analyses reported both up-regulation down-regulation several miRNAs tumour tissues from compared normal tissue, thus supporting development miRNA-based biomarkers. Using comprehensive high-throughput approaches, microarrays, different were proposed potential gliomas. This review aimed summarize evidence about discovered date. Mandatory issues develop clinically validated improve time diagnosis, predicting treatment prognosis are also herein addresses.