Diuretic and Natriuretic Effect of Ebelactone B in Anesthetized Rats by Inhibition of a Urinary Carboxypeptidase Y-Like Kininase.
作者： Masataka Majima , Yoshikazu Kuribayashi , Yasuhiro Ikeda , Keiichi Adachi , Hisao Kato
DOI: 10.1254/JJP.65.79
关键词:
摘要: Abstract. Ebelactone B (EB) (10-7-10−5 M) inhibited dose-dependently carboxypeptidase (CP) Y-like exopeptidase, one of the major kininases separated from rat urine, whereas it neither CPA, CPB or neutral endopeptidase (NEP). Degradation bradykinin (BK) to BK-(1-8) in urine was completely by EB (10−5 with increased generation BK-(1-7). Intraduodenal administration (3 mg/kg) anesthetized rats caused marked diuresis (by 110%) and natriuresis (130%), parallel increase urinary kinin levels (110%). Intravenous infusion a BK antagonist, Hoel40 mg/kg/hr), strongly blocked both EB-induced natriuresis. may be novel type diuretic natriuretic agent that acts increasing levels.
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