Bystander T cell activation and attrition.

摘要: Acquired immunity against viruses relies on the activation of virus-specific T cells to combat and clear virus from infected host. CD8 are essential this process, due their ability differentiate between self non-self antigens presented by class I major histocompatibility (MHC I) found surface majority nucleated (Margulies 1999; Germain Ahmed Biron 1999). Virus-specific that encounter viral antigen in context proper MHC must proliferate, migrate into areas infection, perform effector functions, which include production interferon gamma (IFN-γ) cytolysis (Ahmed Much our understanding process has been obtained using lymphocytic choriomeningitis (LCMV) system. The immune response an acute LCMV infection mice is associated with a massive expansion cells, fueling debate about how much antigen-specific might be consequence “bystander” cell activation.