Obesity and asthma

摘要: Obesity is an important public health problem. An increasing body of data supports the hypothesis that obesity a risk factor for asthma. These include numerous large cross-sectional and prospective studies performed in adults, adolescents, children throughout world. With few exceptions, these indicate increased relative asthma obese overweight demonstrate antedates appears to be particularly issue severe Studies showing improvements subjects who lose weight, as well mice have innate airway hyperresponsiveness (AHR) responses certain triggers also suggest causal relationship between The mechanistic basis this has not been established. It may share some common etiology, such genetic predisposition, effects utero conditions, or are both result other predisposing physical activity diet. However, there plausible biological mechanisms whereby could expected either cause worsen co-morbidities gastroesophageal reflux, complications from sleep-disordered breathing (SDB), at low lung volume, chronic systemic inflammation, endocrine factors, including adipokines reproductive hormones. Understanding lead new therapeutic strategies treatment susceptible population.