Regulation of Motor Neuron Specification by Phosphorylation of Neurogenin 2
作者： Yong-Chao Ma , Mi-Ryoung Song , Jin P. Park , Hsin-Yi Henry Ho , Linda Hu
DOI: 10.1016/J.NEURON.2008.01.037
关键词:
摘要: The mechanisms by which proneural basic helix-loop-helix (bHLH) factors control neurogenesis have been characterized, but it is not known how they specify neuronal cell-type identity. Here, we provide evidence that two conserved serine residues on the bHLH factor neurogenin 2 (Ngn2), S231 and S234, are phosphorylated during motor neuron differentiation. In knockin mice in S234 of Ngn2 were mutated to alanines, occurs normally, specification impaired. phosphorylation at facilitates interaction with LIM homeodomain transcription phosphorylation-dependent cooperativity between may be a general mechanism activities proteins temporally spatially integrated generate wide diversity cell types hallmark nervous system.
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