Bi- or tetra-guanidino-biphenyl compounds as small molecule carriers
作者： David Selwood , Heike Laman , Masahiro Okuyama , Christina Visintin
DOI:
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摘要: The invention relates to compounds of formula: I, or pharmaceutically acceptable a salts thereof, I wherein X1 X2 and X3 are each independently where Y is an alkylene, alkenylene alkynylene group, which may be optionally substituted with one more substituents selected from alkyl, halo, CF3, OH, alkoxy, NH2, CN, NO2 COOH; W absent O, S NH; Rl, R2, R3 R4 H, aryl protecting group Pl; R7, R8 R9 q r 1, 2, 3 4; q' r' 0, 2 3, + equal p 4 5, p' 4, 5; n 3....6; L (Z)mNR5R6 Z hydrocarbyl m 0 1; R5 R6 CO(CH2)jQ1 C=S(NH)(CH2)kQ2 j k Q1 Q2 COOH, chromophore R5, the nitrogen they attached together form.
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