Telomerase therapeutics for cancer: challenges and new directions.
作者： Jerry W. Shay , Woodring E. Wright
DOI: 10.1038/NRD2081
关键词:
摘要: It has been approximately a decade since telomerase was described as an almost universal marker for human cancer. Most tumours not only express but also have very short telomeres, whereas activity is either reduced or absent in normal tissues, making the inhibition of attractive target cancer therapeutics. Here we review current status therapeutics and discuss future opportunities challenges research, including possible relationship with stem cells that could be source chemo-/radioresistance development many advanced cancers.
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