Immunohistochemical study of STAT3, HIF-1α and VEGF in pterygium and normal conjunctiva: Experimental research and literature review.
作者： Ming Yan , Guohua Yang , Shiqi Dong , Yuting Xu , Xiying Wu
DOI:
关键词:
摘要: Purpose Signal transducer and activator of transcription 3 (STAT3) is a DNA-binding protein that regulates various biologic processes, including cell growth, apoptosis, malignant transformation. Abnormal activation STAT3 associated with many diseases, there currently no relevant study on the pathogenesis pterygium. The purpose this was to investigate expression clinical significance STAT3, HIF-1α, VEGF in pterygium at different stages. Methods Immunohistochemistry used levels 50 cases 20 control conjunctival tissue. intensity three proteins evaluated Image-Pro Plus 6.0 image analysis software. Results In group, positive rates for were 82.0%, 86.0%, 84.0%, respectively, while those normal conjunctiva group 40.0%, 25.0%, 15.0%. higher than conjunctiva, advanced statistically significantly stationary (p < 0.01). HIF-1α related length depth corneal invasion level pterygium, but not depth. addition, significant correlation between Conclusions For first time, detected simultaneously Compared highly expressed tissue more It suggested may directly or through promote participate growth angiogenesis Targeting provide new direction treatment
molvis.org参考文章(26)
Mario Nubile, Claudia Curcio, Manuela Lanzini, Roberta Calienno, Manuela Iezzi, Alessandra Mastropasqua, Marta Di Nicola, Leonardo Mastropasqua, None, Expression of CREB in Primary Pterygium and Correlation with Cyclin D1, ki-67, MMP7, p53, p63, Survivin and Vimentin Ophthalmic Research. ,vol. 50, pp. 99- 107 ,(2013) , 10.1159/000347124
M R Pawlus, L Wang, C-J Hu, STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells Oncogene. ,vol. 33, pp. 1670- 1679 ,(2014) , 10.1038/ONC.2013.115
Dalit May, Ahuva Itin, Oded Gal, Hagar Kalinski, Elena Feinstein, Eli Keshet, Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer. Oncogene. ,vol. 24, pp. 1011- 1020 ,(2005) , 10.1038/SJ.ONC.1208325
Walter J. Lukiw, Anna Ottlecz, George Lambrou, Monika Grueninger, Joelle Finley, Hilary W. Thompson, Nicolas G. Bazan, Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Investigative Ophthalmology & Visual Science. ,vol. 44, pp. 4163- 4170 ,(2003) , 10.1167/IOVS.02-0655
Petrus de Jong, Ji-Hun Mo, Alexandra Harris, Jongdae Lee, Eyal Raz, STAT3: An Anti-Invasive Factor in Colorectal Cancer? Cancers. ,vol. 6, pp. 1394- 1407 ,(2014) , 10.3390/CANCERS6031394
Ting Liu, Yangwuyue Liu, Lin Xie, Xiangge He, Ji Bai, Progress in the pathogenesis of pterygium. Current Eye Research. ,vol. 38, pp. 1191- 1197 ,(2013) , 10.3109/02713683.2013.823212
Erika Hoyama, Magda Massae Hata Viveiros, Claudia Shiratori, Deilson Elgui de Oliveira, Carlos Roberto Padovani, Dinesh Selva, Silvana Artioli Schellini, Expression of Vascular Endothelial Growth Factor (VEGF) in Macrophages, Fibroblasts, and Endothelial Cells in Pterygium Treated with 5-Fluorouracil Seminars in Ophthalmology. ,vol. 30, pp. 171- 176 ,(2015) , 10.3109/08820538.2013.835838
Joseph D Fleming, Paul G Giresi, Marianne Lindahl-Allen, Elsa B Krall, Jason D Lieb, Kevin Struhl, STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer Epigenetics & Chromatin. ,vol. 8, pp. 7- 7 ,(2015) , 10.1186/1756-8935-8-7
Jie Yuan, Fei Zhang, Ruifang Niu, Multiple regulation pathways and pivotal biological functions of STAT3 in cancer Scientific Reports. ,vol. 5, pp. 17663- 17663 ,(2016) , 10.1038/SREP17663
Vesna Ljubojevic, Radoslav Gajanin, Ljiljana Amidzic, Zoran Vujkovic, The expression and significance of p53 protein and Ki-67 protein in pterygium Vojnosanitetski Pregled. ,vol. 73, pp. 16- 20 ,(2016) , 10.2298/VSP140428124L