The impact of human papillomavirus genotype on colposcopic appearance: a cross-sectional analysis.

摘要: Objective To study colposcopic performance in diagnosing high-grade cervical intraepithelial neoplasia or cancer (CIN2+ and CIN3+) using characteristics high-risk human papillomavirus (hrHPV) genotyping. Design Cross-sectional multicentre study. Setting Two colposcopy clinics The Netherlands Spain. Population Six hundred ten women aged 17 years older referred for because of abnormal cytology. Methods A smear was obtained. Colposcopists identified the worst lesion, graded their impression scored lesions. Up to four biopsies were collected, including one biopsy from visually normal tissue. Main outcome measures CIN2+ CIN3+, positive HPV16 other HPV types (non-16 hrHPV-positive). Results The mean age HPV16-positive CIN2+ 35.1 years compared with 39.1 years hrHPV (P = 0.002). Sensitivity detect 87.9% (95%CI 83.2–91.5), cut-off ‘any abnormality’. remaining found by a tissue endocervical curettage (ECC). Detection lesion-targeted not different between [119/135; 88.1% 81.2–92.9)] non-16 hrHPV-positive [100/115; 87.0% 79.1–92.3); P = 0.776]. In multivariate analysis, ‘acetowhitening’ [odds ratio (OR) 1.91, 95%CI 1.56–3.17], ‘time appearance’ (OR 1.95, 1.21–3.15) ‘lesion >25% visible cervix’ 2.25, 1.44–3.51) associated CIN2+. Conclusions In this population following European screening practice, HPV16-related lesions detected at younger showed similar as There no relationship any status.