Preserved Oxygenation Despite Reduced Blood Flow in Poststenotic Kidneys in Human Atherosclerotic Renal Artery Stenosis

摘要: Atherosclerotic renal artery stenosis reduces blood flow and perfusion pressures to the poststenotic kidney producing renovascular hypertension threatening glomerular filtration rate. Little is known regarding regional tissue oxygenation in human disease that develops slowly. We compared stenotic contralateral kidneys volume, perfusion, measured by multidetector computed tomography, oxygen level–dependent magnetic resonance values cortex medulla 14 patients with unilateral (mean: 71% quantitative tomography) essential hypertensive during 150 mEq/d of sodium intake renin-angiotensin blockade. Stenotic volume was reduced (118.6±9.9 versus 155.4±13.7 mL; P =0.02), mainly because cortical volume. Tissue similar but lower than (1.5 1.2 mL/min per milliliter; −1 ; =0.006). These data indicate that, although medullary preserved under these conditions.