Environmental fate, distribution and state-of-the-art removal of antineoplastic drugs: A comprehensive insight

作者: Santanu Mukherjee , Dip Mehta , Kiran Dhangar , Manish Kumar , None

DOI: 10.1016/J.CEJ.2020.127184

关键词:

摘要: Abstract Antineoplastics (anticancer agents) i.e. alkylating and non-alkylating agents, topoisomerase inhibitors etc. are classified as the contaminants of emerging concern due to growing about environmental health degradation. Such cytostatic agents contain a suit functional groups (i.e. folic acid/purine/pyrimidine/nitrogen analogues), which render their complex chemistry determine partitioning in aquatic systems. A systematic review recent literature published between 2009 2020 has been presented validate hypothesis that fate, distribution, removal aspects chemotherapeutic depend largely on structural orientation, (and genetic) factors, degree ionization. The key knowledge gaps current challenges opportunities research trends drugs derivatives) environment have identified critically discussed. This provides an overview risk assessment pyrimidine antimetabolites inhibitors, is need hour considering increasing consumption state-of-the-art analytical detection. main focus cocktail mixture tamoxifen, 5-fluorouracil other active metabolites polar, water soluble antineoplastic may accumulation effect species. They can spread drug resistance via interaction with some kinases.

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