Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage

摘要: Abstract Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Increased expression 5-lipoxygenase (5-LO), key enzyme in biosynthesis leukotrienes (LTs), has been reported MS lesions and LT levels are elevated cerebrospinal fluid patients. To determine whether pharmacological inhibition 5-LO attenuates demyelination, MK886, inhibitor, was given to mice fed with cuprizone. Gene protein were increased at peak cuprizone-induced demyelination. Although MK886 did not attenuate demyelination corpus callosum or cortex, it attenuated axonal damage motor deficits reduced microglial activation IL-6 production. These data suggest that during pathway contributes neuroinflammation resulting dysfunction. Thus, may be useful therapeutic treatment diseases CNS.