The use of dopexamine hydrochloride to increase oxygen delivery perioperatively.

作者: Boyd O , Bennett Ed , Grounds Rm

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摘要: Perioperative increases in oxygen delivery may reduce morbidity and mortality certain groups of surgical patients. However positive inotropic drugs, such as dobutamine epinephrine themselves, increase demand. Dopexamine hydrochloride is a new dopamine analogue with action at beta 2-adrenoceptors DA1 receptors, but it possesses no direct alpha-adrenoceptor activity. We assessed the suitability dopexamine to perioperatively eight patients having vascular surgery studied its effects on Oxygen was increased toward 600 mL.min-1.m-2 by intravenous (IV) fluid infusion IV titration hydrochloride. could be preoperatively (375 +/- 43 552 50 mL.min-1.m-2, P being achieved five This without significant total body consumption (114 10 123 7 > 0.05) or rate pressure product (13.7 2.8 x 10(3) 13.5 2.1 mm Hg.beats/min, 0.05). Postoperatively again an (126 (14.2 0.9 provide method for increasing only limited myocardial

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