Corrigendum: Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods

摘要: Myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) is the label given to a that can include long-term flu-like symptoms, profound fatigue, trouble concentrating, and autonomic problems, all of which worsen after exertion. It unclear how many individuals with this diagnosis are suffering from same condition or have underlying pathophysiology, discovery biomarkers would be clarifying. The name “myalgic encephalomyelitis” essentially means “muscle pain related central nervous system inflammation” efforts find diagnostic focused on one more aspects neuroinflammation, periphery brain. As field uncovers relationship between symptoms attention must paid biological mechanisms neuroinflammation issues its potential measurement. current review focuses three methods used study putative in ME/CFS: 1) positron emission tomography (PET) neuroimaging using translocator protein (TSPO) binding radioligand 2) magnetic resonance spectroscopy (MRS) 3) assays cytokines circulating blood cerebrospinal fluid. PET scanning TSPO-binding promising option for studies neuroinflammation. However, methodological difficulties exist both particular technique across ME/CFS literature addressed any results interpretable. We argue vast majority has failed use optimal techniques studying brainstem, despite probable centrality neuroinflammatory causes effects. MRS discussed as less informative but widely available, invasive, expensive imaging existing reviewed. Studies seeking peripheral cytokine “profile” reviewed, reasons lack replication among these studies. innumerable sources variance their measurement make it unlikely consistent replicable profile will ever discovered.