HFE p.C282Y gene variant is associated with varicose veins in Russian population
作者： Ekaterina A. Sokolova , Alexandra S. Shadrina , Kseniya S. Sevost’ianova , Andrey I. Shevela , Evgenii Yu. Soldatsky
DOI: 10.1007/S10238-015-0377-Y
关键词:
摘要: Recently, the association of polymorphism rs1800562 (p.C282Y) in hemochromatosis (HFE) gene with increased risk venous ulceration was shown. We hypothesized that HFE might be involved not only process, but also susceptibility to primary varicose veins. genotyped p.C282Y (rs1800562) and p.H63D (rs1799945) variants patients veins (n = 463) control group (n = 754). In our study, p.282Y variant (rs1800562 A allele) significantly associated (OR 1.79, 95 % CI = 1.11-2.89, P = 0.02). borderline significant reverse p.63D (rs1799945 G leg ulcer development revealed Russians 0.25, CI = 0.06-1.00, P = 0.05), meta-analysis (P = 0.56). conclude can affect developing
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