The role of NKT cells in tumor immunity.

摘要: NKT cells are a relatively newly recognized member of the immune community, with profound effects on rest system despite their small numbers. They true T cell receptor (TCR), but unlike conventional that detect peptide antigens presented by major histocompatibility (MHC) molecules, recognize lipid CD1d, nonclassical MHC molecule. As members both innate and adaptive systems, they bridge gap between these, respond rapidly to set tone for subsequent responses. fill unique niche in providing cellular arm antigens. play effector regulatory roles infectious autoimmune diseases. Furthermore, subsets can distinct sometimes opposing roles. In cancer, type I cells, defined invariant TCR using Valpha14Jalpha18 mice Valpha24Jalpha18 humans, mostly protective, producing interferon-gamma activate NK CD8(+) activating dendritic make IL-12. contrast, II characterized more diverse TCRs recognizing lipids primarily inhibit tumor immunity. Moreover, counter-regulate each other, forming new immunoregulatory axis. Because rapidly, balance along this axis greatly influence other responses follow. Therefore, learning manipulate may be critical devising successful immunotherapies cancer.