Drosophila Behaviour & Gene expression in altered gravity conditions: Comparison between Space and ground facilities

作者: Oliver J. Larkin , F. Javier Medina , Camelia E. Dijkstra , Raúl Herranz , David A. Laván

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摘要: Previous experiments in space (unmanned satellites, shuttle and the International Space Station, ISS), have shown that adult Drosophila flies change their motile behaviour microgravity. A consistent increase motility was found these experiments, but mature (two weeks old) showed less than recently hatched flies. In case of relatively long exposure to microgravity, aging male measured upon return Earth increased, with dying earlier corresponding in-flight 1g centrifuge or ground controls. The older flies, which experienced a smaller motility, did not show this acceleration process. More we performed comparative using simulation facilities. Preliminary random positioning machine (RPM) indicate effects approach on behavior Drosophi l re o f sma e r magn i tude real Further are progress confirm effect. However, when exposed magnetic levitation, simulated weightlessness increased markedly compared controls both inside outside magnet. This altered gravity-related also pronounced more effect at levitation position reproduces results microgravity indicating interest for science approach. Similar being Larger Diameter Centrifuge (LDC) located ESTEC (the Netherlands) 6g, 12g 20g key points hypergravity response Our developmental processes from embryo proceeded normally magnet, RPM LDC. terms gene expression, preliminary ind ica te tha t fec ted se genes under responds general an opposite direction induced by exposure. conducting parallel complete spectrum methods is above studies will be achieved near future.

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