Body composition and fatness patterns in Prader-Willi syndrome: comparison with simple obesity.

作者: Mariana F. Theodoro , Zohreh Talebizadeh , Merlin G. Butler

DOI: 10.1038/OBY.2006.193

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摘要: THEODORO, MARIANA F., ZOHREH TALEBIZADEH, AND MERLIN G. BUTLER. Body composition and fatness patterns in Prader-Willi syndrome: comparison with simple obesity. Obesity. 2006;14:1685–1690. Objective: To characterize the body of PraderWilli syndrome (PWS) subjects compare Research Methods Procedures: Seventy-two individuals (27 PWS deletion, 21 uniparental disomy, 24 obese controls) 10 to 49 years old were studied use DXA. measures obtained, regional fat lean mass characterized. Significant differences assessed Student’s t test ANOVA adjusting for age, gender, BMI. Results: between groups found arms, legs, trunk. Total was significantly lower than trunk, especially legs. Furthermore, two regions (legs trunk) showed significant males. However, females these only No identified deletion disomy subjects. Discussion: Our results demonstrate that do, fact, have an unusual patterns, characterized by reduced tissue increased adiposity, males contributing most more similar females.

参考文章(20)
Katherine M Flegal, Lester R Curtin, Clifford L Johnson, Zuguo Mei, Rong Wei, Cynthia L Ogden, Laurence M Grummer-Strawn, Robert J Kuczmarski, Shumei S Guo, Alex F Roche, 2000 CDC Growth Charts for the United States: methods and development. Vital and health statistics. Series 11, Data from the National Health Survey. pp. 1- 190 ,(2002)
G B Forbes, A distinctive obesity: body composition provides the clue. The American Journal of Clinical Nutrition. ,vol. 65, pp. 1540- 1541 ,(1997) , 10.1093/AJCN/65.5.1540
Anthony P Goldstone, Audrey E Brynes, E Louise Thomas, Jimmy D Bell, Gary Frost, Anthony Holland, Mohammad A Ghatei, Stephen R Bloom, Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome The American Journal of Clinical Nutrition. ,vol. 75, pp. 468- 475 ,(2002) , 10.1093/AJCN/75.3.468
Peter S. W. Davies, C. Joughin, Assessment of body composition in the Prader-Willi syndrome using bioelectrical impedance. American Journal of Medical Genetics. ,vol. 44, pp. 75- 78 ,(1992) , 10.1002/AJMG.1320440118
Merlin G. Butler, Susan L. Christian, Takeo Kubota, David H. Ledbetter, A 5-year-old white girl with Prader-Willi syndrome and a submicroscopic deletion of chromosome 15q11q13 American Journal of Medical Genetics. ,vol. 65, pp. 137- 141 ,(1996) , 10.1002/(SICI)1096-8628(19961016)65:2<137::AID-AJMG11>3.0.CO;2-R
Trina M. Anglin, Physician management of sexually abused children and adolescents Current Problems in Pediatrics. ,vol. 14, pp. 6- 53 ,(1984) , 10.1016/0045-9380(84)90059-8
Merlin G. Butler, F. John Meaney, Catherine G. Palmer, John M. Opitz, James F. Reynolds, Clinical and cytogenetic survey of 39 individuals with Prader-Labhart-Willi syndrome American Journal of Medical Genetics. ,vol. 23, pp. 793- 809 ,(1986) , 10.1002/AJMG.1320230307
MG Butler, D Bittel, Z Talebizadeh, Prader-Willi syndrome and a deletion/duplication within the 15q11-q13 region Journal of Medical Genetics. ,vol. 39, pp. 202- 204 ,(2002) , 10.1136/JMG.39.3.202
Merlin G. Butler, Travis Thompson, Prader-Willi Syndrome: Clinical and Genetic Findings. Endocrinologist. ,vol. 10, ,(2000) , 10.1097/00019616-200010041-00002
F. John Meaney, Merlin G. Butler, Characterization of Obesity in the Prader-Labhart-Willi Syndrome: Fatness Patterning Medical Anthropology Quarterly. ,vol. 3, pp. 294- 305 ,(1989) , 10.1525/MAQ.1989.3.3.02A00080