A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

作者: J. Zhang , A. Bottaro , S. Li , V. Stewart , F.W. Alt

DOI: 10.1002/J.1460-2075.1993.TB06027.X

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摘要: … The mutation that we have introduced replaces the IFy2b promoter region, Fy2b exon, and 3' splice donor site with a neor gene. However, the sequences replaced in our study lie nearly …

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