Combined Radiotherapy and Chemotherapy: Theoretical Considerations and Biological Premises

摘要: Starting point for full realization of clinical achievements combined radiation therapy and chemotherapy in lung cancer is nothing but understanding general theoretical consideration as well basic radiobiological premises chemotherapy. Both are nowadays considered mandatory ingredients any cancer, cancers other tumour sites. More than 30 years ago, four mechanisms through which can interact were established including spatial cooperation, independent cell kill, protection normal tissues enhancement tumor response, the latter frequently replaced by terms such radiosensitization or radio enhancement. Clinical evidence supports importance exploitable mechanisms, although tissue has never been proven. Novel technologies, occasionally changing fractionation pattern new drugs/compounds will set stage scene further verification principles research cancer.