Control of Tumors by the RES

摘要: Attempts to deal with the problem of cancer are, in addition its basic complexity, encumbered by pseudoconflicts diverting attention investigator from more essential tasks. Among them is question as whether a local or systemic disease. Clinical and experimental evidence prove beyond any doubt that neoplasia starts, rare exceptions, at particular sites can be frequently identified exposure known carcinogenic agent. Depending on cellular composition, physiologic anatomic characteristics, various may less resistant specific carcinogens. By same token, overwhelming support mustered for factors playing critical role development progression most cancers. This conclusion based wide variability appearance human animal populations have been exposed identical kinds amounts agents. strikingly illustrated epidemiology occupational environmental cancers, such those caused asbestos smoking man, ionizing radiation man animals. Moreover, unpredictable differences clinical course response therapy encountered patients afflicted seemingly analogous types stages cancer, demand operation host distinguishing one individual other. Although some genetic, hormonal, metabolic, knowledge their exact modus operandi still fragmentary. Within last decades, good has given immunologic capabilities reticuloen-dothelial system (RES) relation resistance neoplasia.