Cytokine Regulation of Immune Tolerance to Tumors

摘要: Publisher Summary Tumors arise from normal self tissues, thus the default pathway to tumor-associated antigens is tolerance—that prevents induction of destructive cellular immune responses. The barriers that prevent antitumor responses are related those inhibit autoimmune diseases, which include mechanisms suppression or deviation under steady state and during wound healing. Cytokines important regulators tolerance tumors. TGF-β most potent pleiotropic regulatory cytokine. Under conditions, inhibits directed at by inhibiting activation differentiation Th1, CTL, NK cells, maintaining peripheral Tregs. This a crucial for tumor tolerance. condition healing, may ensure while promoting healing process. process have critical role in responses, as inflammation associated with invasion resembles