The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator

摘要: Originally described in 2002 as a T cell-costimulatory cytokine, the tumor necrosis factor family member TNF-like 1A (TL1A), encoded by TNFSF15 gene, has since been found to affect multiple cell lineages through its receptor, death receptor 3 (DR3, TNFRSF25) with distinct cell-type effects. Genetic deficiency or blockade of TL1A-DR3 defined number disease states that depend on this cytokine-receptor pair, whereas excess TL1A leads allergic gastrointestinal inflammation stimulation group 2 innate lymphoid cells. Noncoding variants locus are associated susceptibility inflammatory bowel and leprosy, predicting level expression may influence host defense development autoimmune diseases.