Synergistic chemo-photodynamic therapy by "big & small combo nanoparticles" sequential release system.
作者： Li Fan , Saisai Zhao , Xin Jin , Yongsheng Zhang , Chaojun Song
DOI: 10.1016/J.NANO.2017.09.002
关键词:
摘要: Abstract Chemo-photodynamic combination has been manifested great potential for synergistic cancer therapy. Moreover, the efficacy could be significantly enhanced by well-designed sequential release manner of photosensitizers (PSs). Here we propose a “big & small combo nanoparticles (NPbig&small)” system double loading PSs methylene blue (MB) and single absorbing chemotherapeutics drug Gemcitabine hydrochloride (GM·HCl). The “grown-in” MB from NPbig&small show two-peak profile, improve absorbed chemotherapeutic GM·HCl. corresponding profile can illustrated related mathematics function. property was clearly observed through morphological evolution NPs both in water cells TEM. Furthermore, demonstrate well EPR effect improved vitro vivo results. Thus, chemo-photodynamic programmable mechanism provide promising platform that ensures an treatment.
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