Transition from Puberty to Adulthood

摘要: Growth hormone deficiency (GHD) has implications throughout the lifespan. In childhood, reduced linear growth is primary consequence of untreated GHD, while in adulthood, a number abnormalities are associated with phenotype GHD. However, GHD adulthood differs depending on timing onset. Childhood-onset (CO) patients have bone mineral content and lean body mass despite GHRT during childhood. These differences suggest CO developmental. It these developmental deficits that led to focus transition period, spanning from completion puberty into young adulthood. The aim this time normalise composition cardiovascular health long-term reducing morbidity mortality observed hypopituitarism. There evidence at aids reduce deficit muscle bone. This may effect improving physical performance fractures later life; however, epidemiological currently lacking. inconsistent risk increased quality life (QoL) improve GHRT. possible, there some support this, certain patient groups demonstrate worsening profile QoL after more sustained period off More studies required provide endocrinologist adequate information inform treatment decisions. essential both paediatric adult endocrinologists recognise people first foremost. Addressing psychological, social, educational, vocational needs engaging them their ongoing management