Testosterone administration increases insulin-like growth factor-I levels in normal men.

摘要: Although testosterone (T) administration can increase insulin-like growth factor-I (IGF-I) when administered to hypogonadal men, no studies have examined whether this occurs in normal men. The present study was undertaken determine if an IGF-I may be part of the anabolic effect androgens. We enrolled 11 men a randomized, double-blinded cross-over study. Subjects were assigned receive either T enanthate (TE) (300 mg im, each week) or nandrolone (ND) decanoate for 6 weeks. After washout period subjects alternate treatment. Pre- and posttreatment serum analyzed by RIA after acid-ethanol extraction. Results expressed as mean +/- SEM (Table 1). IGF-binding protein-3 measured unchanged TE treatment decreased significantly ND GH levels not different treatment, they tended (1.23 0.28 ng/mL vs. 3.3 1.03 ng/mL) but remained (1.68 0.68 1.89 0.64 ng/mL). Serum total increased 32 0.05 nmol/L TE-treated fell 7 0.02 ND-treated (P < 0.0001). estradiol rose 193.04 19.82 pmol/L although falling 50.65 34.50 0.0002). These data indicate that are given TE, weeks Treatment with did change decrease level major IGF-BP therefore bioavailable group.