Combined Intestinal Trefoil Factor and Epidermal Growth Factor is Prophylactic against Indomethacin-Induced Gastric Damage in the Rat

摘要: 1. The availability of recombinant epidermal growth factor provides a potentially exciting development for the treatment gastrointestinal ulceration. However, because its potent mitogenic activity, there is need strategies which reduce dose required. Intestinal trefoil stimulates mucosal healing without increasing proliferation. Studies were undertaken to examine biological effects rat intestinal and/or human upon epithelial cell functions pertinent protection, using two wounding models. 2. study restitution in vitro demonstrated marked synergistic effect on rate migration wound edge when was used combination with factor. There no increased cellular proliferation due addition cells given alone, or stimulatory treated In model gastric ulceration, presence both and protected against indomethacin-induced lesions. 3. We conclude that therapy could provide more potent, safer approach