A cyclometallated fluorenyl Ir(iii) complex as a potential sensitiser for two-photon excited photodynamic therapy (2PE-PDT).

摘要: A new Ir(iii) cyclometallated complex bearing a fluorenyl 5-substituted-1,10-phenanthroline ligand ([Ir(ppy)2()][PF6], ppy = 2-phenylpyridine) is presented which exhibits enhanced triplet oxygen sensing properties. The efficacy of this to act as photosensitiser for altering the morphology C6 Glioma cells that represent malignant nervous tumours has been evaluated. increased heavy metal effect and related spin-orbit coupling parameters on photophysical properties are evidenced by comparison with Ru(ii) analogues. [Ir(ppy)2()][PF6] shown exhibit relatively high two-photon absorption efficiencies lowest energy MLCT electronic transitions cross sections range from 50 80 Goeppert-Mayer units between 750 800 nm. Quantum yields were measured up 23% Stern-Volmer quenching constant, KSV was determined be 40 bar(-1) in acetonitrile solution, confirming efficiency sensitiser. Preliminary vitro experiments treated [Ir(ppy)2()][PF6], show an efficient sensitizer oxygen, producing cytotoxic singlet ((1)O2) excitation at 740 nm resulting photodynamic effects lead localised cell damage death.