Lack of Correlation Between Growth Hormone Provocative Test Results and Subsequent Growth Rates During Growth Hormone Therapy

摘要: Objectives . To determine whether there is a relationship between the peak GH level in pituitary stimulation tests and growth rate response to treatment with recombinant human hormone (GH). Methods.  We identified 24 843 patients National Cooperative Growth Study database who had not been treated previously therapy divided them into three groups according testing: 1) n = 14 132); 2) ≥10 μg/L ( 7476); 3) no test results reported 3235). rates each group were examined. Results.  The children of responded vigorous increase (means, 8.4 9.5 cm/y) first year, followed by gradual decline then stabilization at 1.0 1.9 cm/y greater than pretreatment values. There large overlaps among groups, but differences significant. The smaller 187) normal responses before increased similarly year (to 7.7 9.2 cm/y), declined rapidly values or lower. Conclusion . Because testing inadequate for diagnosing deficiency, such also determining should be prescribed child short stature. In addition, waning normally growing suggests that this may have sustained benefit these children.