The impact of E-cadherin expression on non-small cell lung cancer survival: a meta-analysis
作者： Ying Wu , Hong-Bing Liu , Ming Ding , Jian-Nan Liu , Ping Zhan
DOI: 10.1007/S11033-012-1827-1
关键词:
摘要: E-cadherin has been implicated in invasiveness and metastasis. However, the clinical prognostic value of decreased expression patients with non-small cell lung cancer (NSCLC) remains unsettled. A meta-analysis eligible studies was performed to quantitatively review correlation survival NSCLC. Thirteen studies, including 2,274 patients, were subjected final analysis. The rate 47.6 % overall 41.4 for stage I disease. combined hazard ratio (HR) 1.41 (95 CI 0.18-1.65; P = 0.001), indicating that had an unfavorable impact on Further, stratified analysis by ethnicity, HR Asians 1.49 1.27-1.71) non-Asians 1.01 1.00-1.02). when only considered, 1.19 0.90-1.47; 0.576), suggesting no survival. Decreased associated poor NSCLC, especially among Asians, but not significantly correlated NSCLC patients.
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