Bilateral Pneumothoraces Hasten Mortality in AIDS Patients Receiving Secondary Prophylaxis with Aerosolized Pentamidine: Association with a Lower Dco Prior to Receiving Aerosolized Pentamidine

摘要: We have administered aerosolized pentamidine (AP) to 48 AIDS patients for secondary prophylaxis of Pneumocystis carinii pneumonia (PCP). Pentamidine 60 mg was by ultrasonic nebulization (Fisoneb) five times during the first two weeks and then every weeks. The mean follow-up 343 ±22 days. PCP recurred in ten patients, 297 ±33 days after starting AP therapy. All responded anti-Pneumocystis therapy but died unrelated reasons (20 percent mortality). Five developed bilateral pneumothoraces 260 ±35 Recurrence could be documented only one patient. 66 ±27 onset pneumothorax. Only 5 33 without recurrence or pneumothorax study period (15 No association found between development age, smoking, previous respiratory infectious problems, time from last initiation therapy, treatment duration PCP. Patients with had a significantly lower Dco (58.6 ± 2.6 predicted) prior than (81.1 ±2.1 no (67 ±2.5 (p