Effects of oral contraceptive steroids on acetaminophen metabolism and elimination

摘要: Plasma acetaminophen elimination was examined in women taking low-dose estrogen oral contraceptive (OC) steroids and age-matched control women. Fractional rates of fractional clearances were calculated for each the metabolic pathways, including oxidation, sulfation, glucuronidation. The cysteine adduct mercapturic acid derivative used as an index oxidative biotransformation, a potentially toxic route metabolism acetaminophen. clearance rose from 287 +/- 13 ml/min to 470 51 OC steroids, whereas t1/2 decreased 2.40 0.14 hr 1.67 0.16 hr. rate by glucuronidation increased sulfation did not differ significantly values subjects. also significantly, but change. These data suggest that plasma results drug, although mechanism is known.