Prostaglandins, not the leukotrienes, regulate Cl−/HCO3− exchange (DRA, SLC26A3) in villus cells in the chronically inflamed rabbit ileum
作者： Palanikumar Manoharan , Steven Coon , Walter Baseler , Shanmuga Sundaram , Ramesh Kekuda
DOI: 10.1016/J.BBAMEM.2012.08.003
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摘要: Abstract Previously studies have demonstrated that Cl−/HCO3− exchange was inhibited during chronic intestinal inflammation secondary to decrease in the affinity of exchanger for Cl− rather than number transporters. Arachidonic acid metabolites (AAM) are elevated mucosa chronically inflamed small intestine. However, their role alteration enteritis unknown. Inhibition AAM formation with arachidonyl trifluoro methylketone (ATMK) rabbit intestine reversed diminished activity. Kinetics showed reversal restoration altered transporter. Downstream regulation inhibition by determined be cyclooxygenase pathway since only piroxicam treatment exchange. Further, DRA shown primary villus cells. and molecular indicated mechanism transporter without a change BBM expression. Thus our data mediate inflammation.
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