Comparing the effects of age, pubertal development, and symptom profile on cortisol rhythm in children and adolescents with autism spectrum disorder.

摘要: Previous studies in children with autism spectrum disorder (ASD) have shown elevated evening cortisol; however, few examined diurnal rhythm adolescents ASD. Adolescence is a time of significant physical and psychological change, dysregulation the hypothalamic-pituitary-adrenal axis may put ASD at increased risk for internalizing disorders, such as anxiety depression. The extent to which cortisol levels are associated age, puberty symptom profile was 113 youth (ages 7-17) typical development. Salivary samples were collected over 3 days home, 4 times per day (waking, 30-min post-waking, afternoon, evening). Results showed had higher blunted slope relative TD youth. Pubertal development age predictors cortisol, compared study extends previous reports reveal high adolescence well. Adolescents also show significantly slope, be symptoms. Findings suggest persists across ASD, thus emphasizing need identify potential negative effects excess exposure on health individuals. Autism Res 2018, 11: 110-120. © 2017 International Society Research, Wiley Periodicals, Inc. LAY SUMMARY:Elevations stress hormone, during indicate from changes throughout (ASD). current shows that pubertal related increases this maladaptive elevation not going away age. These elevations other symptoms warrant further investigation