THE ANTAGONISTIC EFFECT OF CARCINOGENIC HYDROCARBONS ON MURINE VIRUS-INDUCED LEUKEMIAS
作者： Alvin Gale Fiscus
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摘要: Previous studies using a combination of carcinogenic polycyclic aromatic hydrocarbons and oncogenic as well nononcogenic viruses have always shown an enhancement • the disease^process. In this investigation, 7,12-dimethylbenz(a)anthracene (IMRA) 3-methylcholanthrene (3-MC) friend Rauscher murine leukemia viruses, reverse result was obtained indicated by increased latent periods, survival times smaller spleen weights. Tenfold dilutions both Priend ranging from 10"1 to 10~7 were made stock pools. The individual inoculated intraperitoneally into three groups five BALB/c mice each. treated in follow ing manner immediately a:fter virus inoculation: Group I These animals received at weekly intervals subcutaneously 100 ug LMBA or 3-MC dissolved 0.1 ml. corn oil. II 200 EMBA 0.05 reagent grade acetone applied hairless skin each mouse. III only acted untreated controls. observed daily, weights recorded. Portions liver,
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