Study of PNIPAAm-PEG thermo-sensitive copolymer micelle and Application as drug carrier for icariin
作者： Xiaoyan Xu , Taotao Liu , Enke Feng , Wen Zhang , Yan Li
DOI: 10.1109/ICCME.2013.6548305
关键词:
摘要: A series of thermally responsive copolymers PNIPAAm-PEG were prepared through RAFT polymerization. Their molecular structures verified by 1H NMR spectroscopy and GPC. The temperature-dependent characteristics study has revealed that PNIP AAm-PEG exhibits a lower critical solution temperature (LCST) about 34~42°C with the PNIPAAm:PEG weight ratio 1:1 to 10:1. When PNIPAAm:PEG=I.8:1, polymer LCST 37.8°C, which is very close body temperature. micelles also showed nearly 85% encapsulation efficiency for icariin dependent release. These results indicate promising drug carrier icariin, icariin-PNIPAAm-PEG great potential in bone defect disease treatment.
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