Cellular genetic tools to control oncolytic adenoviruses for virotherapy of cancer

摘要: Key challenges facing cancer therapy are the development of tumor-specific drugs and implementation potent multimodal treatment regimens. Oncolytic adenoviruses, featuring cancer-selective viral cell lysis spread, constitute a particularly interesting drug platform towards both goals. First, as complex biological agents, adenoviruses allow for rational by genetic incorporation targeting mechanisms that exert their function at different stages replication cycle. Secondly, therapeutic genes implementing diverse cell-killing activities can be inserted into oncolytic adenovirus genome without loss potential, thus deriving “one-agent combination therapy”. This article reviews an intriguing approach to derive which is insert cellular regulatory elements genomes control virus gene expression. has been thoroughly investigated optimized during last decade transcriptional expression wide panel tumor types. More recently, further mechanisms, such mRNA stability translation regulation, have reported tools control. Consequently, with remarkable specificity profile prostate cancer, gastrointestinal cancers, liver breast lung melanoma, other cancers were derived. Such profiles engineering new generations improved potency enhancing binding entry or expressing genes. Clearly, viruses great potential innovative antitumor drugs—towards targeted therapy.