Antagonism of membrane compression effects by high pressure gas mixtures in a phospholipid bilayer system

摘要: Abstract Binary mixtures of helium with nitrogen, xenon or nitrous oxide were applied to suspensions phosphatidylcholine-cholesterol vesicles determine those lipid soluble gases which would exactly antagonize the membrane rigidifying effect 100 ATA compression. A previous study has shown that initial application compression by gas produces a significant reduction in fluidity phospholipid bilayer. However, as high pressure dissolves into region it creates disorder and increases fluidity. Fluidity bilayer at equilibrium represents sum compression-ordering dissolved-gas disordering effects is dependent on gas/lipid partition coefficient particular gas. The beneficial narcotic added Trimix ameliorate HPNS deep divers may be due balance solubility-disordering achieved within nerve membrane. It therefore valuable achieve these two result zero net change an established ATA. 88% 3.8% 2.8% resulted our model system graph percent needed produce function pressure, however, was nonlinear. This suggest ratio must varied pressure. While good for certain components membrane, does not allow protein-lipid gas-protein interactions. data presented thus aid understanding but are yet incomplete precise use predicting diving mixtures.