Quantitative Computed Tomography Detects Air Trapping due to Asthma

摘要: Objective: The purpose of this study was to prospectively see if quantitative computed tomography (QCT) could separate asthmatic patients from normal control subjects. QCT results were also correlated with the pulmonary function tests (PFT) that done on both and Subjects methods: Eighteen adult nonsmoking asthmatics 22 subjects entered into study. Quantitative CT performed at level transverse aorta just above diaphragm end inspiration expiration in all subjects: 10-mm 1.5-mm collimation using a high spatial frequency algorithm used obtain examinations. percent pixels below —900 Hounsfeld units, pixel index, each axial images lungs calculated for subject Pulmonary testing included determination FEV 1 , FVC, FRC, RV, TLC. Unpaired Student's t test analysis data statistically compare Linear regression PFT Results: When scans expiration, immediately superior diaphragm, mean index significantly higher compared individuals (mean 0.16 vs 4.45 asthmatics, p lesser extent, FVC. Conclusion: Expiratory is useful method assess air trapping patients. abnormal lung as determined by has significant correlation PFTs reflect may be helpful assessing degrees present other diseases affecting airways.