The immunology and genetics of resistance of sheep to Teladorsagia circumcincta

摘要: Teladorsagia circumcincta is one of the most economically important gastrointestinal nematode parasites sheep in cool temperate regions, to which show genetically-varying resistance infection. This a very common parasite and viable production requires extensive use anthelmintic drugs. However, emergence drug-resistant has stimulated search for alternative control strategies curb losses. Lambs become infected soon after weaning begin burden within 8–10 weeks continual an acquired characteristic mediated by development parasite-specific antibodies. paper describes immunology associated with susceptibility, focussing on differential T cell activation that regulates specific effector mechanisms. It continues summarizing methods used identify genes could be exploited as molecular markers selection resistance. In particular it focusses link between understanding infection identification candidate selection.