Acceleration of viral replication and up-regulation of cytokine levels by antimalarials: implications in malaria-endemic areas.
作者： P Seth , A K Singh , K K Banaudha , S Madhavan , G S Sidhu
DOI: 10.4269/AJTMH.1999.61.180
关键词:
摘要: Antimalarial drugs are widely used in malaria endemic areas, both for chemoprophylaxis and also empirically to treat patients presenting with fever. Previously, we have reported that chloroquine enhances the severity of Semliki forest virus (SFV) encephalomyocarditis infection. The studies presented herein show a broad spectrum antimalarial augmented replication SFV mice, concomitant greater tissue damage up-regulation mRNA levels various inflammatory cytokine genes, including interleukin-1 receptor antagonist (IL-1Ra), II-1alpha, IL-1beta, IL-6, IL-12p40, interferon-gamma inducing factor. Furthermore, IL-1Ra production RAW cells vitro. Since is known be up-regulated number viral infections, propose further enhancement its expression by antimalarials may responsible increased infection our studies. Thus, widespread use malaria-endemic areas predispose population infections. Further progress delineate mechanism(s) involved acceleration replication.
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