作者: Nicholas E. Simpson , Zhanquan He , Jeffrey L. Evelhoch
DOI: 10.1002/(SICI)1522-2594(199907)42:1<42::AID-MRM8>3.0.CO;2-Z
关键词:
摘要: This paper considers potential problems encountered when using the Kety approach to measure perfusion in small laboratory animals with nuclear magnetic resonance (NMR) tracer uptake methods: a) need arterial input function (AIF) each animal; b) sensitivity heterogeneity; c) low signal-to-noise ratio (SNR); and d) influence of changes AIF. A method estimate AIF rats is presented that derives an from time course a passing through carotid chamber. The results computer simulations indicate common obtained one set can be used for estimations another if delivered as dose optimal data analysis (fitting vs. integration approach) dictated by SNR heterogeneity. Experimental strategies are suggested minimize effects individual could distort estimates.