Deuterium NMR Tissue Perfusion Measurements Using the Tracer Uptake Approach: I. Optimization of Methods

作者: Nicholas E. Simpson , Zhanquan He , Jeffrey L. Evelhoch

DOI: 10.1002/(SICI)1522-2594(199907)42:1<42::AID-MRM8>3.0.CO;2-Z

关键词:

摘要: This paper considers potential problems encountered when using the Kety approach to measure perfusion in small laboratory animals with nuclear magnetic resonance (NMR) tracer uptake methods: a) need arterial input function (AIF) each animal; b) sensitivity heterogeneity; c) low signal-to-noise ratio (SNR); and d) influence of changes AIF. A method estimate AIF rats is presented that derives an from time course a passing through carotid chamber. The results computer simulations indicate common obtained one set can be used for estimations another if delivered as dose optimal data analysis (fitting vs. integration approach) dictated by SNR heterogeneity. Experimental strategies are suggested minimize effects individual could distort estimates.

参考文章(27)
M. E. Raichle, J. Markham, P. Herscovitch, W. R. W. Martin, M. A. Mintun, Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation. The Journal of Nuclear Medicine. ,vol. 24, pp. 790- 798 ,(1983)
Tissue Perfusion Inhomogeneity During Early Tumor Growth in Rats Journal of the National Cancer Institute. ,vol. 62, pp. 387- 395 ,(1979) , 10.1093/JNCI/62.2.387
J. J. Ackerman, C. S. Ewy, N. N. Becker, R. A. Shalwitz, Deuterium nuclear magnetic resonance measurements of blood flow and tissue perfusion employing 2H2O as a freely diffusible tracer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 4099- 4102 ,(1987) , 10.1073/PNAS.84.12.4099
Hidehiro Iida, Iwao Kanno, Shuichi Miura, Matsutaro Murakami, Kazuhiro Takahashi, Kazuo Uemura, Error analysis of a quantitative cerebral blood flow measurement using H215O autoradiography and positron emission tomography, with respect to the dispersion of the input function Journal of Cerebral Blood Flow and Metabolism. ,vol. 6, pp. 536- 545 ,(1986) , 10.1038/JCBFM.1986.99
S. Schultz-Hector, J. Kummermehr, H.D. Suit, Vascular architecture of experimental tumours--influence of tumour volume and transplantation site. International Journal of Radiation Biology. ,vol. 60, pp. 101- 107 ,(1991) , 10.1080/09553009114551631
GM Tozer, S Lewis, A Michalowski, V Aber, The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma. British Journal of Cancer. ,vol. 61, pp. 250- 257 ,(1990) , 10.1038/BJC.1990.46
J R Ewing, C A Branch, J A Helpern, M B Smith, S M Butt, K M Welch, Cerebral blood flow measured by NMR indicator dilution in cats. Stroke. ,vol. 20, pp. 259- 267 ,(1989) , 10.1161/01.STR.20.2.259
J.B. Larcombe-McDouall, J. Mattiello, C.L. McCoy, N.E. Simpson, M. Seyedsadr, J.L. Evelhoch, Size dependence of regional blood flow in murine tumours using deuterium magnetic resonance imaging. International Journal of Radiation Biology. ,vol. 60, pp. 109- 113 ,(1991) , 10.1080/09553009114551651
James Mattiello, Jeffrey L. Evelhoch, Relative volume-average murine tumor blood flow measurement via deuterium nuclear magnetic resonance spectroscopy. Magnetic Resonance in Medicine. ,vol. 18, pp. 320- 334 ,(1991) , 10.1002/MRM.1910180207