Design of a new pulsatile bioreactor for tissue engineered aortic heart valve formation.

摘要: Evidence has been gathered that biomechanical factors have a significant impact on cell differentiation and behavior in vitro cultures. The aim of this bioreactor is to create physiological environment which tissue engineered (TE) aortic valves seeded with human cells can be cultivated during period several days. consists 2 major parts: the left ventricle (LV) afterload consisting compliance, representing elastic function large arteries, series resistance, mimicking arterioles capillaries. TE valve placed between LV compliance. With controllable stroke volume frequency, hydrodynamic conditions changed over wide range. This study resulted prototype compact pulsatile flow system for creation valves. In addition biocompatibility used materials performed.