Relative Survival Analysis of 252 Patients With COPD Receiving Long-term Oxygen Therapy

摘要: Objectives A survival analysis was conducted on patients with COPD receiving long-term oxygen therapy (LTOT) to compare two different statistical methods. Methods We used a multivariate crude (observed) model (Cox) and relative (Hakulinen). Only the latter is able correct by adjusting it normal life expectancy of studied patients. Patients Two hundred fifty-two hypoxemic (207 male) requiring LTOT were included. Mean PaO 2 69 years (SE: 9.9). They had severe bronchial obstruction: mean retention: PaCO 45.6 (7.1) mm Hg. By December 31, 1995, 189 died (75%) 13 (5%) unavailable for follow-up. Results The overall poor: 80.9% after 1 year, 67.1% years, 34.7% 5 7.1% 10 years. In (Cox), negative prognostic factors age hypercapnia. (Hakulinen), corrected expectancy, 82.8% 70.8% 41.5% 10.25% final model, no longer significant only bad factor hypercapnia risk 1.97 (1.16 3.34). Conclusion This work shows inadequacy Cox observed when comes appreciating real impact age, because confusing associated expectancy.