Monitoring perchlorate exposure and thyroid hormone status among raccoons inhabiting a perchlorate-contaminated site.

作者: Philip N. Smith , Sarah J. Utley , Stephen B. Cox , Todd A. Anderson , Scott T. McMurry

DOI: 10.1007/S10661-005-6031-5

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摘要: Perchlorate is a water soluble anion that readily accumulated in vegetation. It inhibits uptake of iodide into thyroid gland tissue, thereby reducing production hormones. Potential raccoon food items including berries, fish, and vegetation collected at contaminated site contained quantifiable concentrations perchlorate as determined by ion chromatography. Therefore, we monitored resident raccoons for exposure to examining plasma hormone concentrations. Resulting analytical data failed demonstrate among likely consumed along perchlorate-contaminated bodies. There were no correlations between triiodothyronine or thyroxine stimulating concentrations, but significantly higher 2000 than 2001 (p = 0.0081). These suggest natural attenuation remedial efforts initiated January may have reduced inhabiting this from 2001. Temporal, spatial, factors limited our ability quantify raccoons, however, do not indicate currently are risk significant subsequent effects.

参考文章(17)
W. Nelson Beyer, Erin E. Connor, Sarah Gerould, Estimates of soil ingestion by wildlife Journal of Wildlife Management. ,vol. 58, pp. 375- 382 ,(1994) , 10.2307/3809405
Lu Yu, Jaclyn E Cañas, George P Cobb, William A Jackson, Todd A Anderson, Uptake of perchlorate in terrestrial plants Ecotoxicology and Environmental Safety. ,vol. 58, pp. 44- 49 ,(2004) , 10.1016/S0147-6513(03)00108-8
T. A. Anderson, T. H. Wu, Extraction, cleanup, and analysis of the perchlorate anion in tissue samples. Bulletin of Environmental Contamination and Toxicology. ,vol. 68, pp. 684- 691 ,(2002) , 10.1007/S001280308
Judithanne P. Hare, Remediation of perchlorate contamination at NWIRP McGregor, Texas Federal Facilities Environmental Journal. ,vol. 10, pp. 33- 38 ,(2000) , 10.1002/FFEJ.3330100405
L Narayanan, G.W Buttler, K.O Yu, D.R Mattie, J.W Fisher, Sensitive high-performance liquid chromatography method for the determination of low levels of perchlorate in biological samples Journal of Chromatography B. ,vol. 788, pp. 393- 399 ,(2003) , 10.1016/S1570-0232(03)00037-0
Jeffrey Fisher, Paula Todd, Dave Mattie, Dick Godfrey, Latha Narayanan, Kyung Yu, Preliminary development of a physiological model for perchlorate in the adult male rat: a framework for further studies. Drug and Chemical Toxicology. ,vol. 23, pp. 243- 258 ,(2000) , 10.1081/DCT-100100113
O Yu Kyung, Latha Narayanan, David R Mattie, Richard J Godfrey, Paula N Todd, Teresa R Sterner, Deirdre A Mahle, Michael H Lumpkin, Jeffrey W Fisher, The pharmacokinetics of perchlorate and its effect on the hypothalamus-pituitary-thyroid axis in the male rat. Toxicology and Applied Pharmacology. ,vol. 182, pp. 148- 159 ,(2002) , 10.1006/TAAP.2002.9432