Is the skin barrier abnormal in dogs with atopic dermatitis?

作者: Thierry Olivry

DOI: 10.1016/J.VETIMM.2011.07.014

关键词:

摘要: In mammalian skin, the stratum corneum exerts a barrier function that protects from transepidermal water loss and penetration of exogenous molecules, such as allergens, environment. Recently, skin defects have been shown to be prime importance in pathogenesis human atopic dermatitis. this review, we summarize latest research data pertinent dogs with At time writing, there is increasing evidence defect likely exists This dysfunction characterized by abnormal intercellular lipid lamellae, morphology, reduced ceramide content and, some but not all dogs, filaggrin expression. association these changes, higher than normal canine skin. Furthermore, inflammation appears worsen It remains unknown, however, if changes observed are primary (i.e. genetic origin) or secondary also even clinically Finally, whether therapeutic intervention aimed at restoring dysfunctional any clinical benefit has yet proven unequivocally.

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