Can we use fixed ambient air monitors to estimate population long-term exposure to air pollutants? The case of spatial variability in the Genotox ER study

摘要: Associations between average total personal exposures to PM2.5, PM10, and NO2 concomitant outdoor concentrations were assessed within the framework of Genotox ER study. It was carried out in four French metropolitan areas (Grenoble, Paris, Rouen, Strasbourg) with participation, each site, 60-90 nonsmoking volunteers composed two groups equal size (adults children) who Harvard Chempass multipollutant sampler during 48 h along different seasons ("hot" "cold"). In center, selected so as live (home work/school) three urban sectors contrasted terms air pollution (one highly exposed traffic emissions, one influenced by local industrial sources, a background environment). parallel exposure measurements, fixed ambient monitoring station surveyed same pollutants sector. A linear regression model accommodated where dependent pollutant-specific variable difference, for subject, over period. The explanatory variables areas, sectors, season, age group. While particles underestimated monitors, almost all cities, seasons, groups, differences lower and, general, other direction. Relationships levels varied across sectors. These results suggest that using assess populations, epidemiological studies long-term effects or risk assessment setting, calls some caution. Comparison PM is inherently disturbed indoor sources activities patterns. Discrepancies measurement devices regional may also strongly influence how relate population exposure. Much attention should be given selection most appropriate sites according study objectives.