Modified TALL-104 cells to treat cancer

作者: Daniela Santoli , Giovanni Rovera , Alessandra Cesano

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摘要: This invention provides a method of using modified human cytotoxic TALL-104 cell line, which is characterized by activity against tumor cells. More particularly, the comprises treating bone marrow cells an immunosuppressed mammalian patient with line and reinjecting treated into patient, as treatment hematological malignancies. Also provided are effective safe methods use in manufacture veterinary composition for adoptive therapy canine lymphoma feline leukemias.

参考文章(46)
Daniela Santoli, Giovanni Rovera, Alessandra Cesano, Cytotoxic T-ALL cell lines and uses therefor ,(1992)
Hoxie Ja, Nowell Pc, Lange B, Bishop J, Cesano A, Santoli D, The severe combined immunodeficient (SCID) mouse as a model for human myeloid leukemias. Oncogene. ,vol. 7, pp. 827- 836 ,(1992)
N Heerema, S C Raimondi, P C Nowell, D Santoli, P E Steinherz, R O'Connor, B J Lange, J Minowada, E B Arenson, Pediatric leukemia/lymphoma with t(8;14)(q24;q11). Leukemia. ,vol. 6, pp. 613- 618 ,(1992)
A Cesano, R O'Connor, PC Nowell, B Lange, SC Clark, D Santoli, Establishment of a karyotypically normal cytotoxic leukemic T-cell line from a T-ALL sample engrafted in SCID mice Blood. ,vol. 81, pp. 2714- 2722 ,(1993) , 10.1182/BLOOD.V81.10.2714.2714
ROSEMARY O'Connor, ALESSANDRA Cesano, BRENT L Kreider, BEVERLY Lange, STEVEN C Clark, PETER C Nowell, JANET Finan, GIOVANNI Rovera, DANIELA Santoli, Growth factor-dependent differentiation along the myeloid and lymphoid lineages in an immature acute T lymphocytic leukemia. Journal of Immunology. ,vol. 145, pp. 3779- 3787 ,(1990)
D Santoli, S Visonneau, S C Clark, A Cesano, Cellular and molecular mechanisms of activation of MHC nonrestricted cytotoxic cells by IL-12. Journal of Immunology. ,vol. 151, pp. 2943- 2957 ,(1993)
Yoshimi Kawade, Haruhiko Kikuchi, Junkoh Yamashita, Youli Zu, Yuziro Namba, Masao Hanaoka, Shinichi Miyatake, Yoshihiko Watanabe, Kiyoshi Nishihara, Tsuneaki Sakata, Augmentation of Tumor Targeting in a Line of Glioma-specific Mouse Cytotoxic T-Lymphocytes by Retroviral Expression of Mouse γ-Interferon Complementary DNA Cancer Research. ,vol. 48, pp. 4730- 4735 ,(1988)
D Santoli, R O'Connor, G Rovera, S C Clark, A Cesano, P Phillips, B Lange, T L Colt, Synergistic and antagonistic effects of IL-1 alpha and IL-4, respectively, on the IL-2-dependent growth of a T cell receptor-gamma delta+ human T leukemia cell line. Journal of Immunology. ,vol. 144, pp. 4703- 4711 ,(1990)
Charles M. Balch, Arabella B. Tilden, Kyogo Itoh, Interleukin 2 Activation of Cytotoxic T-Lymphocytes Infiltrating into Human Metastatic Melanomas Cancer Research. ,vol. 46, pp. 3011- 3017 ,(1986)