Free Cytosolic Adenosine Sensitively Signals Myocardial Hypoxia

摘要: The first description of the coronary vasodilatory action adenosine was published in 1929 by Drury and Szent-Gyorgyi. However, it only 1963 that Berne independently Gerlach demonstrated cardiac muscle can produce (Gerlach et al. 1963). This has led to hypothesis my be major importance adjustment blood flow metabolic demands heart (Berne In past 20 years numerous studies have tested implications (for review see Rubio 1979; Feigl 1983; Olsson Bunger 1987). Although we learned many important details concerning site mechanism formation-of adenosine, as well its mode (Schrader Sparks Bardenheuer 1986), is still a matter debate what extent this vasoactive nucleoside mediates changes under physiological conditions.